How much does it cost to drive from Chicago to St. Louis?

Driving fuel + tolls cost is estimated from modelled regional fuel baselines and your vehicle's MPG.

How far is Chicago from St. Louis?

Approximate driving distance and time are computed from modelled highway routing.

Cost to drive

Chicago to St. Louis in a 2025 Toyota Camry

Fuel-cost estimate from Chicago, IL to St. Louis, MO driving a 2025 Toyota Camry, using modelled regional fuel baselines, estimated driving distance, tolls, and recommended refuel stops along the route.

Total cost

$39.5

Distance

312 mi

Drive time

5h 12m

Fuel

9.8 gal

Gas: $3.57/gal

Modelled state estimates rebased on Nov 8, 2026 to a $4.04/gal national regular-gas benchmark; not measured AAA/EIA state prices. Diesel estimates are unchanged. Distances and stops are estimates, not navigation directions.

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Make

Model

Year

Fuel

gas

Efficiency

32 MPG

Tank

15.8 gal

Range

506 mi

Cost breakdown

Fuel (9.8 gal @ $3.57/gal route avg)$34.82

Tolls (estimated)$4.68

Cost per mile$0.127

Refuel stops0

Range per fill506 mi

Vehicle

Make / ModelToyota Camry

Year2025

Fuel typegas

MPG (combined)32

Tank (gal)15.8

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FAQ

Driving from Chicago, IL to St. Louis, MO costs about $39.5 one way in fuel and estimated tolls for a Toyota Camry using modelled regional fuel baselines.